Author/Editor		Lind, Maggie; Hayes, Alan; Caprnda, Martin; Petrovič, Danijel; Rodrigo, Luis; Kruzliak, Peter; Zulli, Anthony
Title		Inducible nitric oxide synthase
Type		članek
Vol. and No.		, št. Vol. 93
Publication year		2017
Volume		str. 370-375
ISSN		1950-6007 - Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie
Language		eng
Abstract		Nitric oxide synthases (NOS) are a family of isoforms responsible for the synthesis of the potent dilator nitric oxide (NO). Expression of inducible NOS (iNOS) occurs in conditions of inflammation, and produces large amounts of NO. In pathological conditions iNOS is regarded as a harmful enzyme and is proposed to be a major contributor to diseases of the cardiovascular system such as atherosclerosis. In this review, we address the notion that iNOS is a detrimental enzyme in disease and discuss its potentially beneficial roles. Additionally, we describe other molecules associated with iNOS in diseases such as atherosclerosis, and current research on therapeutic inhibitors tested to reduced pathology associated with cardiovascular diseases (CVD).
Keywords		cardiovascular diseases cyclooxygenase-2 oxidative stress bolezni srca in ožilja ciklooksigenaza-2 oksidativni stres