Author/Editor		Redenšek, Sara; Dolžan, Vita
Title		Pharmacogenetics of psoriasis treatment
Type		članek
Source		In: An interdisciplinary approach to psoriasis Rijeka : InTech
Publication year		2017
Volume		str. [185]-209
Language		eng
Abstract		Psoriasis is a chronic systemic, immune-mediated disorder of unknown aetiology, usually presenting with typical inflammatory skin lesions and/or joint manifestations, but systemic inflammation that may lead to the development of co-morbidities may also be present. First-line therapy encompasses local cutaneous treatment and phototherapy, but with more severe symptoms or systemic course, systemic treatment with methotrexate (MTX), immunosuppressant cyclosporine, retinoid acitretin or biologicals may be used. Treatment response varies between patients in terms of efficacy and/or toxicity, which could, among other reasons, be due to genetic differences between patients. Approximately 10%30% of patients experience adverse drug reactions with MTX treatment, leading to discontinuation of MTX mostly due to hepatotoxicity. Around 15% of patients experience adverse events when treated with biologicals; however, the most frequent reason for discontinuation is inefficacy or loss of the initially favourable response over time. Inefficacy or occurrence of adverse drug reactions cannot be predicted, so genetic biomarkers of drug response in combination with clinical data could be helpful in treatment planning. Several polymorphic genes have already been associated with treatment outcome, most of them involved in drug metabolism, transport and target pathways. Genetic biomarkers could be helpful in personalized care of psoriasis patients in order to prevent adverse events or predict inefficacy of a certain drug.
Keywords		psoriasis pharmacogenetics genetic polymorphisms luskavica farmakogenetika genetski polimorfizmi