Author/Editor     Knez, Damijan; Sova, Matej; Košak, Urban; Gobec, Stanislav
Title     Dual inhibitors of cholinesterases and monoamine oxidases for Alzheimer's disease
Type     članek
Vol. and No.     Letnik 9, št. 8
Publication year     2017
Volume     str. 811-832
ISSN     1756-8927 - Future medicinal chemistry
Language     eng
Abstract     Accumulating evidence indicates a solid relationship between several enzymes and Alzheimer's disease. Cholinesterases and monoamine oxidases are closely associated with the disease symptomatology and progression and have been tackled simultaneously using several multifunctional ligands. This design strategy offers great chances to alter the course of Alzheimer's disease, in addition to alleviation of the symptoms. More than 15 years of research has led to the identification of various dual cholinesterase/monoamine oxidase inhibitors, while some showing positive outcomes in clinical trials, thus giving rise to additional research efforts in the field. The aim of this review is to provide an update on the novel dual inhibitors identified recently and to shed light on their therapeutic potential.
Descriptors     Alzheimerjeva bolezen
Keywords     dualni zaviralci
multitarčni ligandi
holinesteraza