Author/Editor | Janžič, Urška; Kern, Izidor; Janžič, Andrej; Čavka, Luka; Čufer, Tanja | |
Title | PD-L1 expression in squamous-cell carcinoma and adenocarcinoma of the lung | |
Type | članek | |
Vol. and No. | Letnik 51, št. 3 | |
Publication year | 2017 | |
Volume | str. 357-362 | |
ISSN | 1318-2099 - Radiology and oncology | |
Language | eng | |
Abstract | With introduction of immunotherapy (IT) into the treatment of advanced non-small-cell lung cancer (NSCLC), a need for predictive biomarker became apparent. Programmed death ligand 1 (PD-L1) protein expression is most widely explored predictive marker for response to IT. We assessed PD-L1 expression in tumor cells (TC) and immune cells (IC) of squamous-cell carcinoma (SCC) and adenocarcinoma (AC) patients. We obtained 54 surgically resected tumor specimens and assessed PD-L1 expression by immunohistochemistry after staining them with antibody SP142 (Ventana, USA). Clinicopathological characteristics were acquired from the hospital registry database. Results were analyzed according to cut-off values of % 5% and % 10% of PD-L1 expression on either TC or IC. 29 (54%) samples were AC and 25 (46%) were SCC. PD-L1 expression was significantly higher in TC of SCC compared to AC at both cut-off values (52% vs. 17%, p = 0.016 and 52% vs. 14%, p = 0.007, respectively) no difference in PD-L1 expression in IC of SCC and AC was found. In AC alone, PD-L1 expression was significantly higher in IC compared to TC at both cut-off values (72% vs. 17%, p < 0.001 and 41% vs. 14%, p = 0.008, respectively), while no significant difference between IC and TC PD-L1 expression was revealed in SCC. Our results suggest a significantly higher PD-L1 expression in TC of SCC compared to AC, regardless of the cut-off value. PD-L1 expression in IC is high in both histological subtypes of NSCLC, and adds significantly to the overall positivity of AC but not SCC. | |
Descriptors | Adenokarcinom Onkologija Imunoterapija | |
Keywords | lung cancer squamous-cell lung cancer adenocarcinoma tumor cells immune cells PD-L1 expression |