Author/Editor		Kenda, RB; Kaplar-Vučevac, M; Čavič, M; Meglič, A
Title		Zdravljenje bakterijske okužbe sečil dojenčkov, otrok in mladostnikov s ceftriaksonom (lendacin)
Translated title		Ceftriaxone (lendacin) in the treatment of urinary tract infections in infants, children and adolescents
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 64, št. 9
Publication year		1995
Volume		str. 479-81
Language		slo
Abstract		Background. The aim of the study was to compare the efficacy of ceftriaxone (Lendacin) and netilmicin (Netromycine) in the treatment of acute urinary tract infections in infants, children and adolescents. Methods. A total of 77 patients included into an open comparative trials were randomly allocated to receive either the study or the control drug. Patients treated for bacterial urinary tract infection at the Department of Pediatric Nephrology of the Pediatric Clinic between April 1993 and April 1994 were considered eligible for inclusion. The study group included 38 children, 31 girls and 7 boys, aged 2 months to 14 years (mean age 3.23 years) while the control group comprised 39 children, 29 girls and 10 boys, aged 1 month to 16 years (mean age 4.5 years). Results. The therapeutic effect was assessed as very good and good in 37/38 (97.4 percent) patients in the study group versus 37/39 (94.4 percent) patients in the control group. In each group there was one report of mild gastrointestinal adverse reactions. Treatment failure was reported in one patient in the study group and two patients in the control group. The difference in the therapeutic effect between the two groups was not statistically significant (p great. th. 0.05). Conclusions. The results obtained demonstrated the efficacy of ceftriaxone in the treatment of acute urinary tract infections in pediatric patients.
Summary		Izhodišča. Namen dela je bil primerjati učinkovitost ceftriaksona (Lendacin) z netilmicinom (Netromycine) pri zdravljenju akutnih okužb sečil dojenčkov, otrok in mladostnikov. Metode. V odprtem primerjalnem poskusu smo z naključnim izborom 77 bolnikov razdelili na preiskovano in kontrolno skupino. Vključeni so bili bolniki, ki so med aprilom 1993 in aprilom 1994 na Kliniki za otroško nefrologijo Pediatrične klinike prebolevali bakterijsko okužbo sečil. V preiskovani skupini je bilo 38 otrok, starih od dveh mesecev do 14 let (povprečna starost 2,23 leta). Deklic je bilo 31, dečkov sedem. V kontrolni skupini je bilo 39 otrok, starih od enega meseca do 16 let (povprečna starost 4,5 leta), od tega 29 deklic in deset dečkov. Rezultati. Uspeh zdravljenja smo ocenili kot zelo dober in dober pri 37/38 (97,4 odst.) bolnikih preiskovane skupine in pri 37/39 (94,9 odst.) bolnikih kontrolne skupine. V vsaki skupini smo opazili po en primer blagih prebavnih stranskih pojavov. Zdravljenje je bilo nezadovoljivo pri enem bolniku preiskovane skupine in pri dveh bolnikih kontrolne skupine. Razlike v uspehu zdravljenja med skupinama statistično niso značilne (p večje kot 0,05). Zaključki. Ceftriakson je bil v naši raziskavi uspešen antibiotik za zdravljenje akutnih okužb sečil pri otrocih.
Descriptors		URINARY TRACT INFECTIONS CEFTRIAXONE CHILD