Author/Editor		Merlini, Luciano; Bonaldo, Paolo; Marzetti, Emanuele
Title		Pathophysiological mechanisms of sarcopenia in aging and in muscular dystrophy
Type		monografija
Place		Lausanne
Publisher		Frontiers
Publication year		2017
Volume		str. 248 str.
ISBN		978-2-88919-684-5
Language		eng
Abstract		Loss of muscle mass and increased fibrosis characterize both sarcopenia of aging and muscular dystrophy. Research is increasingly showing that these two conditions also share several pathophysiological mechanisms, including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autophagy, decline in satellite cells, increased generation of reactive oxygen species, and abnormal regulation of signaling and stress response pathways. This Research Topic will cover several mechanisms involved in aging and dystrophic sarcopenia and explore the therapeutic potential of various strategies for intervention
Keywords		sarcopenia muscular dystrophy skeletal muscle frailty autophagy