Author/Editor		Lončar, Goran; Božić, Biljana; Nešković, Aleksandar; Cvetinović, Nataša; Lainščak, Mitja; Prodanović, Nenad; Düngen, Hans-Dirk; Haehling, Stephan; Radojćić, Zoran; Trippel, Tobias D.
Title		Androgen status in non-diabetic elderly men with heart failure
Type		članek
Vol. and No.		Letnik 20, št. 4
Publication year		2017
Volume		str. 215-224
ISSN		1473-0790 - The aging male : the official journal of the International Society for the Study of the Aging Male
Language		eng
Abstract		We aimed at evaluating androgen status (serum testosterone [TT] and estimated free testosterone [eFT]) and its determinants in non-diabetic elderly men with heart failure (HF). Additionally, we investigated its associations with body composition and long-term survival. METHODS: Seventy three non-diabetic men with HF and 20 healthy men aged over 55%years were studied. Echocardiography, 6-min walk test, grip strength, body composition measurement by DEXA method were performed. TT, sex hormone binding globulin, NT-proBNP, and adipokines (adiponectin and leptin) were measured. All-cause mortality was evaluated at six years of follow-up. RESULTS: Androgen status (TT, eFT) was similar in elderly men with HF compared to healthy controls (4.79%%%1.65 vs. 4.45%%%1.68%ng/ml and 0.409%%%0.277 vs. 0.350%%%0.204%nmol/l, respectively). In HF patients, TT was positively associated with NT-proBNP (r=%0.371, p%=%0.001) and adiponectin levels (r%=%0.349, p%=%0.002), while inverse association was noted with fat mass (r%=%-0.413, p%<%0.001). TT and eFT were independently determined by age, total fat mass and adiponectin levels in elderly men with HF (p%<%0.05 for all). Androgen status was not predictor for all-cause mortality at six years of follow-up. CONCLUSIONS: In non-diabetic men with HF, androgen status is not altered and is not predictive of long-term outcome.
Keywords		testosteron srčno popuščanje moški preživetje testosterone heart failure men survival