| Author/Editor | Zupan, Janja | |
| Title | Mezenhimske matične celice v sinovijskem sklepu kot orodje za raziskave osteoartroze | |
| Translated title | Synovial joint-derived mesenchymal stem cells as tools to study osteoarthritis | |
| Type | članek | |
| Source | In: VI. osteološki dnevi : strokovni sestanek, namenjen zdravnikom, ki obravnavajo osteoporozo in njene posledice, 13. in 14. oktober 2017, v Mariboru Maribor : Univerzitetni klinični center | |
| Publication year | 2017 | |
| Volume | str. 183-191 | |
| Language | slv | |
| Abstract | Degenerativne bolezni in poškodbe mišično-skeletnega sistema vplivajo na izvajanje naših vsakodnevnih aktivnosti. Redke populacije mutipotentnih celic imenovane mezenhimske matične/stromalne celice (MSC) se nahajajo znotraj številnih tkiv mišično-skeletnega sistema odraslih organizmov, kjer predstavljajo vir progenitorjev za regeneracijo poškodovanih tkiv. Z uporabo modernih transgenih živalskih modelov so bile identificirane številne subpopulacije MSC, ki prispevajo k tvorbi tkiv tekom embrionalnega razvoja in ohranijo sposobnost regeneracije tkiv tudi v odrasli dobi. V tem prispevku podajamo kratek pregled raziskav in vitro in in vivo na področju MSC v sinovijskem sklepu s poudarkom na naših rezultatih o novi subpopulaciji MSC v sinovijski ovojnici. Te celice so potomke zgodnjih progenitorskih celic, ki se pojavijo v prvih vidnih strukturah sklepa tekom embrionalnega razvoja in se ohranijo v majhnem deležu tudi v odrasli dobi. Dokazali smo, da so te celice hondroprogenitorji s sposobnostjo regeneracije poškodovanega hrustanca in celo rekonstrukcije sinovijskega sklepa na novo. MSC iz sinovijske ovojnice in tudi ostalih struktur sinovijskega sklepa imajo velik potencial ne le za uporabo v regenerativni medicini, ampak tudi kot pomembno orodje v raziskavah osteoartroze in drugih mišično-skeletnih bolezni.Degenerative disorders and injuries of the musculoskeletal system affect our every-day life activities. Rare multipotent populations called mesenchymal stem/stromal cells (MSCs) reside within several tissues of the adult musculoskeletal system as a source of progenitors to replenish damaged tissues. Numerous studies utilizing sophisticated transgenic animal models have identified different MSCs populations that contribute to tissue formation during development and retain specific ability to regenerate musculoskeletal tissues in adult life. Here we give a brief overview on MSCs, in particular those resident in adult synovial joint, and shortly explain their in vitro and in vivo research focusing on our recently identified novel subpopulation of synovial MSCs. The novel subpopulation is a progeny of early progenitors that form the very first synovial joint during embryonic development and retain as rare population in adult life. We showed that these cells are chondroprogenitors featuring capabilities of regenerating cartilage following injury and even forming synovial joint de novo. Not only these and other synovial joint-derived MSCs have great potential in regenerative medicine, they present a unique tool to study osteoarthritis and other musculoskeletal disorders as well. | |
| Descriptors | Osteoartroza | |
| Keywords | mezehimske matične celice sinovijski sklep sinovijska ovojnica stromalne celice |