Author/Editor		Hauptman, Nina; Jevšinek Skok, Daša; Glavač, Damjan
Title		Noncoding RNA alterations in cancer molecular pathways
Type		članek
Source		In: Cancer and Noncoding Rnas : volume 1 London : Academic Press
Publication year		2018
Volume		str. 247-268
Language		eng
Abstract		Cancer development and progression include many cellular processes, among which cellular signaling networks play crucial roles. The hallmarks of cancer cells are gained through the deregulation of these signaling pathways, which result in the evasion of apoptosis, invasion, angiogenesis, metastasis, and increased proliferation. Signaling network activity can be changed with many diverse mechanisms at different levels. Signal transduction is also regulated by noncoding RNAs (ncRNAs), including microRNA (miRNA) and long noncoding RNA (lncRNA). miRNAs function as posttranscriptional regulators of gene expression, while lncRNAs can function as transcriptional, posttranscriptional, or epigenetic gene regulators. As gene regulators, ncRNAs are included in promoting or suppressing different cell processes and biological functions during cancer development. In this chapter, we will discuss miRNAs and lncRNAs as regulators in signaling networks.
Keywords		rak nekodirane spremembe RNK molekularne poti raka cancer noncoding RNA alterations cancer molecular pathways