Author/Editor		Starc, B
Title		Vpliv sufentanila in fentanila na plazemsko koncentracijo krvnega sladkorja in kalija pri bolnikih med dolgotrajnimi operacijami
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		1995
Volume		str. 35
Language		slo
Abstract		Operation is very stressful for the patient. The underlying need of the body to respond to an insult is the basis of big physiological changes. Most of these changes are the result of the activation of the central nervous system which induces increased levels of stress hormones. The endocrine response results in altered metabolism of carbohydrates as well as in modifications of intracellular and extracellular potassium concentrations. We were interested in the relationship between plasma levels of glucose and potassium and general anesthesia with inhaled anesthetic isoflurane and opiates sufentanil or fentanyl during prolonged anesthetic procedures. The measurements were performed in 40 patients during plastic reconstructive operation by periodic sampling of blood and determination of plasma glucose and potassium levels. We had to maintain stable conditions during anesthesia and operation therefore it was necessary to remove all factors which could influence plasma glucose and potassium concentrations. There was not a statistically significant difference in plasma glucose and potassium levels between the group who were anesthetized with sufentanil and the group of patients who recieved fentanyl. Plasma glucose concentration was observed to increase during surgery. The increase was greater soon after the beginning of anesthesia and operation, then later on till the end of operation. Plasma potassium concentration was decreased also soon after the beginning of anesthesia and operation but the difference was not statistically significant. Later during the operation plasma pota ssium levels remained constant. The increased plasma glucose level at the beginning of anesthesia and operation was attributed to the effect of catecholamines because the stress at the time was the greatest. We conclude that the activation of stress hormones during long lasting plastic reconstructive operation changes mostly plasma glucose concentrations.(trunc.)
Descriptors		ANESTHESIA, GENERAL SUFENTANIL FENTANYL BLOOD GLUCOSE POTASSIUM MIDAZOLAM PREANESTHETIC MEDICATION THIOPENTAL VECURONIUM BROMIDE