Author/Editor		Harjola, Veli-Pekka; Mullens, Wilfried; Banaszewski, Marek; Bauersachs, Johann; Chioncel, Ovidiu; Collins, Sean P.; Doehner, Wolfram; Filippatos, Gerasimos; Flammer, Andreas J.; Lainščak, Mitja
Title		Organ dysfunction, injury and failure in acute heart failure
Type		članek
Vol. and No.		Letnik 19, št. 7
Publication year		2017
Volume		str. 821-836
ISSN		1388-9842 - European journal of heart failure
Language		eng
Abstract		Organ injury and impairment are commonly observed in patients with acute heart failure (AHF), and congestion is an essential pathophysiological mechanism of impaired organ function. Congestion is the predominant clinical profile in most patients with AHF; a smaller proportion presents with peripheral hypoperfusion or cardiogenic shock. Hypoperfusion further deteriorates organ function. The injury and dysfunction of target organs (i.e. heart, lungs, kidneys, liver, intestine, brain) in the setting of AHF are associated with increased risk for mortality. Improvement in organ function after decongestive therapies has been associated with a lower risk for post-discharge mortality. Thus, the prevention and correction of organ dysfunction represent a therapeutic target of interest in AHF and should be evaluated in clinical trials. Treatment strategies that specifically prevent, reduce or reverse organ dysfunction remain to be identified and evaluated to determine if such interventions impact mortality, morbidity and patient-centred outcomes. This paper reflects current understanding among experts of the presentation and management of organ impairment in AHF and suggests priorities for future research to advance the field.
Keywords		večorgansko popuščanje srčno popuščanje akutni srčni zastoj venski zastoj multiple organ failure heart failure acute heart failure venous congestion