| Author/Editor | Antonić, J; Rakar, S | |
| Title | Colour and pulsed Doppler US and tumour marker CA 125 in differentiation between benign and malignant ovarian masses | |
| Type | članek | |
| Source | Anticancer Res | |
| Vol. and No. | Letnik 15, št. 4 | |
| Publication year | 1995 | |
| Volume | str. 1527-32 | |
| Language | eng | |
| Abstract | Background. Colour and pulsed Doppler flow imaging have been proposed as methods that may be useful in differentiating benign from malignant ovarian masses. It was hypothesised that the detection of neovascularisation with abnormal, low-resistance blood flow peculiar to malignant tumours is possible, which is characterised with angleindependent Doppler indices Pl and Rl (pulsatility and resistance index, respectively). Tumour marker CA 125 SC (serum concentration) was found to be elevated in 80-85 percent of patients with serous epithelial ovarian cancer and in a lower percentage in other ovarian cancers, with levels over 35/ml suggestive of malignancy. in our study we wanted to determine whether colour and pulsed Doppler US and CA 125 SC can be used to differentiate benign from malignant ovarian masses and whether, by combining the methods, the results can be even improved. methods. ovarian masses identified by sonography in 71 patients aged 35 years or more were confirmed at surgery (n=61) or endoscopy (n=4) or followe up to resolution with US (n=6). Colour and pulsed Doppler US were used to identify intratumoral areas of vascularisation and to calculate the lowest Pl and RI for each ovarian mass. CA 125 CS were measured. Results. In 16 of 18 ovarian malignancies and 28 of 53 benign masses, areas of intratumoral vascularisation were detected with colour Dopppler US (p=0.002). Pl and Rl values displayed considerable overlap between malignant and bening lesions and the differences were not significant. Mean CA 125 SC was higher in malignant than in bening masses (p= less th. 0.0001). For cut-off at 35U/ml, sensitivity (SE), specificity (SP), positive predictive value (PPV) and negative predictive value (NPV) for ovarian cancer were 83 percent, 74 percent, 79 percent and 75 percent respectively. Either CA 125 SC more th.(trunc.) | |
| Descriptors | OVARIAN NEOPLASMS ULTRASONOGRAPHY, DOPPLER, COLOR ULTRASONOGRAPHY, DOPPLER, PULSED DIAGNOSIS, DIFFERENTIAL CA-125 ANTIGEN ADULT |