Author/Editor     López, Fernando; Lund, Valerie J.; Suárez, Carlos; Snyderman, Carl H.; Saba, Nabil F.; Robbins, K. Thomas; Vander Poorten, Vincent; Strojan, Primož; Mendenhall, William M.; Rinaldo, Alessandra; Ferlito, Alfio
Title     The impact of histologic phenotype in the treatment of sinonasal cancer
Type     članek
Vol. and No.     Letnik 34, št. 10
Publication year     2017
Volume     str. 2181-2198
ISSN     0741-238X - Advances in therapy
Language     eng
Abstract     The management of sinonasal cancer is a challenge due to its low occurrence and anatomical and significant diversity of histological types. The therapeutic modality used should be tailored individually according to the histology, tumour stage, molecular profile and previous treatments. The clinical management of sinonasal cancer has improved greatly owing to developments in endoscopic surgery and precision radiotherapy. Complete surgical resection is the mainstay of sinonasal malignancies' management but multimodality therapy is associated with improved outcomes in certain histologies. The recognition of various histological types with biological behaviours more suitable for non-surgical modalities has allowed treatment protocols to become more tailored to the disease. In this review we aim to describe and to summarise the current data guiding the management of sinonasal cancer with emphasis on phenotypic variation.
Keywords     endoskopska kirurgija
histologija
onkologija
obnosne votline
endoscopic surgery
histology
oncology
paranasal cavities