Author/Editor     Cvetinović, Nataša; Isaković, Andjelka M.; Lainščak, Mitja; Düngen, Hans-Dirk; Marković Nikolić, Nataša; Lončar, Goran
Title     Procalcitonin in heart failure
Type     članek
Vol. and No.     Letnik 11, št. 10
Publication year     2017
Volume     str. 893-903
ISSN     1752-0363 - Biomarkers in medicine
Language     eng
Abstract     Although procalcitonin (PCT) was evaluated for the first time in the setting of heart failure (HF) in 1999, its utility in HF patients is still under examination. Patients with HF have significantly higher plasma PCT concentrations than healthy subjects and PCT levels are associated with severity of HF. It has been confirmed that higher levels of PCT are associated with worse outcomes, such as increased mortality and higher rate of rehospitalization, in HF patients with no evidence of infection. Furthermore, it has been approved that PCT-guided antibiotic treatment in HF patients reduces duration of antibiotic therapy and improves outcomes. This review summarizes current evidence from the published literature of the usefulness and limitations of PCT as a biomarker in HF.
Keywords     biološki označevalci
srčno popuščanje
infekcije
prokalcitonin
biomarker
heart failure
infection
procalcitonin