Author/Editor		Kulbacka, Julita; Paczuska, Joanna; Rembiałkowska, Nina; Saczko, Jolanta; Kiełbowicz, Zdisław; Kinda, Wojciech; Liszka, Bartłomiej; Kotulska, Małgorzata; Kos, Bor; Miklavčič, Damijan; Tozon, Nataša; Čemažar, Maja
Title		Electrochemotherapy combined with standard and CO[sub]2 laser surgeries in canine oral melanoma
Type		članek
Vol. and No.		Letnik 54, št. 4
Publication year		2017
Volume		str. 181-186
ISSN		1580-4003 - Slovenski veterinarski zbornik = Slovenian veterinary research
Language		eng
Abstract		Oral melanomas commonly occur in elderly dogs resulting in darkly pigmented areas of the mouth, tongue and gums. The main object of this study was a severe melanoma diagnosed in the jaw of a 15-year-old dog and its palliative treatment with electrochemotherapy. The tumour spread throughout the jaw including bones. Electrochemotherapy (ECT) with bleomycin and calcium solution (CaCl2) was combined with standard and CO2 laser surgeries. The treatment resulted in good local control of the tumour mass after one ECT session with bleomycin and a second ECT session with calcium ions solution. ECT significantly reduced bleeding and enhanced success of the surgery. The combination of ECT with surgical debulking resulted in rapid recovery and regaining of physiological activities, including normal feeding by the dog.This case demonstrates that the protocol combining ECT and surgery is promising in palliative melanoma treatment.
Keywords		melanom ust oralni melanom elektrokemoterapija eksperimentalna onkologija psi melanom v ustni votlini CO2 laser bleomicin kalcijevi ioni oral melanoma electrochemotherapy eksperimental oncology canine melanoma CO2 laser bleomycin calcium ions