Author/Editor		Pleskovič, Aleš; Šantl-Letonja, Marija; Cokan Vujkovac, Andreja; Nikolajević-Starčević, Jovana; Gazdikova, Katarina; Caprnda, Martin; Gaspar, Ludovit; Kruzliak, Peter; Petrovič, Danijel
Title		C-reactive protein as a marker of progression of carotid atherosclerosis in subjects with type 2 diabetes mellitus
Type		članek
Vol. and No.		Letnik no. 3, št. Vol. 46
Publication year		2017
Volume		str. 187-192
ISSN		0301-1526 - VASA. Zeitschrift für Gefasskrankheiten
Language		eng
Abstract		This prospective study was designed to evaluate the effect of inflammatory markers on the presence and progression of subclinical markers of carotid atherosclerosis in a 3.8-year follow-up period in patients with type 2 diabetes mellitus (T2DM). PATIENTS AND METHODS: A total of 595 subjects with T2DM were enrolled. Subclinical markers of carotid atherosclerosis (carotid intima media thickness (CIMT), plaque thickness, and plaques presence) were assessed with ultrasound at the time of recruitment and again after 3.8 years. Subjects with T2DM were divided into 2 groups according to the plasma high sensitive C-reactive protein (hs-CRP) levels (subjects with hs-CRP % 2 mg/L and subjects with hs-CRP below 2 mg/L). RESULTS: Subjects with T2DM and hs-CRP levels % 2 mg/L had higher CIMT in comparison with subjects with T2DM and hs-CRP levels below 2 mg/L, and higher incidence of plaques/unstable plaques in comparison with subjects with T2DM and hs-CRP levels below 2 mg/L. Multivariate logistic regression analysis found the association between the HDL cholesterol level and presence of plaques, whereas the inflammatory marker hs-CRP was not associated with subclinical markers of progression of carotid atherosclerosis. Multiple linear regression analysis found the association between the hs-CRP levels and either CIMT progression rate or a change in the number of sites with plaques in a 3.8-year follow-up. CONCLUSIONS: We demonstrated an association between the inflammatory marker hs-CRP and either CIMT or incidence of plaques/unstable plaques at the time of recruitment in Caucasians with T2DM. Moreover, we found the association between hs-CRP levels and either CIMT progression rate or a change in the number of sites with plaques in a 3.8-year follow-up in subjects with T2DM.
Keywords		carotid atherosclerosis inflammation type 2 diabetes mellitus karotidna ateroskleroza vnetje sladkorna bolezen tipa 2