Author/Editor		Chowdhury Haque, Helena; Velebit Marković, Jelena; Mekjavić, Igor B.; Eiken, Ola; Kreft, Marko; Zorec, Robert
Title		Systemic hypoxia increases the expression of DPP4 in preadipocytes of healthy human participants
Type		članek
Vol. and No.		Letnik 126, št. 2
Publication year		2018
Volume		str. 91-95
ISSN		0947-7349 - Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
Language		eng
Abstract		Dipeptidyl peptidase 4 (DPP4) is a transmembrane glycoprotein involved in protein degradation. Due to its action on incretins, which increase insulin secretion, DPP4 is considered a therapeutic target for type 2 diabetes. Here we have studied the role of single and combined effects of hypoxia and inactivity on the expression of DPP4 in human adipose tissue of 12 adult normal-weight males. Fat biopsies were obtained at baseline and after each of three experimental campaigns. The results revealed that in isolated human preadipocytes the expression of DPP4 was significantly increased by exposure of participants to hypoxia. Physical inactivity per se had no apparent effect on the DPP4 expression. It is concluded that DPP4 may be a marker to monitor indirectly tissue hypoxia, as occurs in obese subjects.
Keywords		dipeptidyl peptidase 4 adipose differentiation hypoxia dipeptidil peptidaza 4 maščobna diferenciacija hipoksija