Author/Editor		Kovač, Valerija; Čurin-Šerbec, Vladka
Title		Prion proteins without the glycophosphatidylinositol anchor
Type		članek
Vol. and No.		, št. Vol. 13
Publication year		2017
Volume		str. 1-5
ISSN		1177-2719 - Biomarker insights
Language		eng
Abstract		Prion protein (PrP) is a biomolecule that is involved in neuronal signaling, myelinization, and the development of neurodegenerative diseases. In the cell, PrP is shed by the ADAM10 protease. This process generates PrP molecules that lack glycophosphatidylinositol anchor, and these molecules incorporate into toxic aggregates and neutralize toxic oligomers. Due to this dual role, these molecules are important biomarkers for neurodegenerative diseases. In this review, we present shed PrP as a potential biomarker, with a focus on PrP226*, which may be the main biomarker for predicting neurodegenerative diseases in humans.
Keywords		Prionska bolezen Alzheimerjeva bolezen nevrodegenerativna bolezen Prion disease Alzheimer disease neurodegenerative disease