Author/Editor     Kovač, Valerija; Čurin-Šerbec, Vladka
Title     Prion proteins without the glycophosphatidylinositol anchor
Type     članek
Vol. and No.     , št. Vol. 13
Publication year     2017
Volume     str. 1-5
ISSN     1177-2719 - Biomarker insights
Language     eng
Abstract     Prion protein (PrP) is a biomolecule that is involved in neuronal signaling, myelinization, and the development of neurodegenerative diseases. In the cell, PrP is shed by the ADAM10 protease. This process generates PrP molecules that lack glycophosphatidylinositol anchor, and these molecules incorporate into toxic aggregates and neutralize toxic oligomers. Due to this dual role, these molecules are important biomarkers for neurodegenerative diseases. In this review, we present shed PrP as a potential biomarker, with a focus on PrP226*, which may be the main biomarker for predicting neurodegenerative diseases in humans.
Keywords     Prionska bolezen
Alzheimerjeva bolezen
nevrodegenerativna bolezen
Prion disease
Alzheimer disease
neurodegenerative disease