Author/Editor		Burja, Blaž; Kuret, Tadeja; Sodin-Šemrl, Snežna; Lakota, Katja; Rotar, Žiga; Ješe, Rok; Mrak Poljšak, Katjuša; Žigon, Polona; Thallinger, Gerhard G.; Feichtinger, J.; Čučnik, Saša; Tomšič, Matija; Praprotnik, Sonja; Hočevar, Alojzija
Title		A concise review of significantly modified serological biomarkers in giant cell arteritis, as detected by different methods
Type		članek
Vol. and No.		Letnik 17, št. 2
Publication year		2018
Volume		str. 188-194
ISSN		1568-9972 - Autoimmunity reviews
Language		eng
Abstract		Giant cell arteritis (GCA) is a primary systemic vasculitis present in subjects older than 50 years with involvement of large- and medium-sized arteries. Early diagnosis for GCA is essential to prevent serious complications, such as permanent vision loss and/or cerebrovascular events. Elevated inflammatory cytokines, with acute phase and other proteins dominate large- and medium-sized arteries leading to stenosis or occlusion of arterial lumen. To date, there are no reliable serological markers for monitoring GCA. The review aims to provide concise overview of published GCA studies in order to: a) identify significantly changed serological biomarkers in GCA and compare the influences of techniques for marker evaluation and b) investigate most promising markers in GCA using analyte frequency and meta-analysis.
Keywords		giant cell arteritis biomarkers serology giant celični arteritis biomarkerji serologija