Author/Editor     Thiele, Holger; Akin, I.; Sandri, Marco; Fuernau, Georg; Waha, S. de; Meyer-Saraei, R.; Nordbeck, P.; Geisler, T.; Noč, Marko; Goslar, Tomaž
Title     PCI strategies in patients with acute myocardial infarction and cardiogenic shock
Type     članek
Vol. and No.     Letnik 377, št. 25
Publication year     2017
Volume     str. 2419-2432
ISSN     0028-4793 - The New England journal of medicine
Language     eng
Abstract     Background In patients who have acute myocardial infarction with cardiogenic shock, early revascular - ization of the culprit artery by means of percutaneous coronary intervention (PCI) improves outcomes. However, the majority of patients with cardiogenic shock have multivessel dis - ease, and whether PCI should be performed immediately for stenoses in nonculprit arteries is controversial. Methods In this multicenter trial, we randomly assigned 706 patients who had multivessel disease, acute myocardial infarction, and cardiogenic shock to one of two initial revascularization strategies: either PCI of the culprit lesion only, with the option of staged revascularization of nonculprit lesions, or immediate multivessel PCI. The primary end point was a compos - ite of death or severe renal failure leading to renal-replacement therapy within 30 days after randomization. Safety end points included bleeding and stroke. Results At 30 days, the composite primary end point of death or renal-replacement therapy had occurred in 158 of the 344 patients (45.9%) in the culprit-lesion-only PCI group and in 189 of the 341 patients (55.4%) in the multivessel PCI group (relative risk, 0.83; 95% confidence interval [CI], 0.71 to 0.96; P = 0.01). The relative risk of death in the culprit-lesion-only PCI group as compared with the multivessel PCI group was 0.84 (95% CI, 0.72 to 0.98; P = 0.03), and the relative risk of renal-replacement therapy was 0.71 (95% CI, 0.49 to 1.03; P = 0.07). The time to hemodynamic stabilization, the risk of catecholamine therapy and the duration of such therapy, the levels of troponin T and creatine kinase, and the rates of bleeding and stroke did not differ significantly between the two groups. Conclusions Among patients who had multivessel coronary artery disease and acute myocardial infarc - tion with cardiogenic shock, the 30-day risk of a composite of death or severe renal failure leading to renal-replacement therapy was lower among those who initially underwent PCI of the culprit lesion only than among those who underwent immediate multivessel PCI.
Keywords     acute myocardial infarction
cardiogenic shock
percutaneous coronary intervention (PCI)
akutni miokardni infarkt
kardiogeni šok
perkutani koronarni poseg (PCI)