Author/Editor		Haigentz, Missak; Suárez, Carlos; Strojan, Primož; Rodrigo, Juan Pablo; Rinaldo, Alessandra; Bradford, Carol R.; Corry, June; Takes, Robert P.; Ferlito, Alfio
Title		Understanding interactions of smoking on prognosis of HPV-associated oropharyngeal cancers
Type		članek
Vol. and No.		Letnik 35, št. 3
Publication year		2018
Volume		str. 255-260
ISSN		0741-238X - Advances in therapy
Language		eng
Abstract		The new 8th edition AJCC/UICC staging system for human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC), developed to account for improved survival outcomes over HPV-negative cancers, includes anatomic features strictly associated with tumor-node-metastasis (TNM) and does not account for patient-specific characteristics that may impact prognosis. This commentary evaluates the evidence of smoking as an adverse prognostic factor in HPV-associated OPSCC. We review the multifactorial biological, clinical, and social/behavioral characteristics of smokers with OPSCC that impact outcomes, discuss current challenges with incorporating smoking history in prognostic classifications, and consider opportunities for future investigation.
Keywords		rak glave in vratu HPV humani papilomski virus orofaringealni ploščatocelični rak head and neck cancer HPV OPSCC oropharyngeal squamous cell carcinoma