Author/Editor		Tepeš, Bojan; Bračko, Matej; Novak-Mlakar, Dominika; Stefanovič, Milan; Štabuc, Borut; Frković-Grazio, Snježana; Maučec Zakotnik, Jožica
Title		Results of the FIT-based national colorectal cancer screening program in Slovenia
Type		članek
Vol. and No.		Letnik 51, št. 6
Publication year		2017
Volume		str. e52-e59
ISSN		0192-0790 - Journal of clinical gastroenterology
Language		eng
Abstract		Background: Colorectal cancer (CRC) is one of the most common malignancies in the western world. Objective: We aimed to assess the first round of fecal immunochemical test (FIT)-based National CRC screening program (NCSP). Methods: In the NCSP conducted in Slovenia, a FIT and colonoscopy for those tested positive was used. The NCSP central unit sent 536,709 invitations to Slovenian residents age 50 to 69 years old between 2009 and 2011. The adherence rate was 56.9% (303,343 participants). FIT was positive in 6.2% (15,310) of the participants (men, 7.8%; women, 5.0%; P<0.01). A total of 13,919 unsedated colonoscopies were performed with the cecal intubation rate of 97.8%. Results: The overall adenoma detection rate was 51.3% [95% confidence interval (CI), 50.5%-52.1%] of which 61.0% (95% CI, 59.9%-62.1%) was in men, and 39.1% (95% CI, 37.8%-40.3%) in women (P<0.01). The mean number of adenoma per positive colonoscopy was 1.94 (95% CI, 1.90-1.97). Adenoma, advanced adenoma, or cancer were found in 7732 (55.5%) colonoscopies. A total of 862 (6.2%) CRC cases were found. Only 161 (18.7%) carcinomas were situated in the right colon. A total of 597 (70.2%) patients with cancer were in the early clinical stages (N, negative; 194 22.8%) of all cancers were cured with only endoscopic resection. Conclusions: In the NCSP, CRC was found in 6.2% of those participants attending colonoscopy, with 81.3% of carcinomas found in the left colon. A localized clinical stage was found in 70.2% participants. In 22.8% of CRC patients, cancer was cured with endoscopic resection only.
Keywords		SVIT rak črevesja nacionalni programi preventiva