Author/Editor     Fister, Petja; Robek, Domen; Paro Panjan, Darja; Mazić, Uroš; Lenasi, Helena
Title     Decreased tissue oxygenation in newborns with congenital heart defects
Type     članek
Vol. and No.     Letnik 59, št. 2
Publication year     2018
Volume     str. 71-78
ISSN     0353-9504 - Croatian medical journal
Language     eng
Abstract     Aim To compare regional tissue oxygenation (rSO 2 ) in the brain, intestine, and kidney between newborns with and without congenital heart defects (CHD). Methods This observational case-control study was con- ducted at the Neonatal Department of Children's Hospital Ljubljana between December 2012 and April 2014. It in- cluded 35 newborns with CHD and 30 healthy age- and sex-matched controls. CHD were assessed echocardio - graphically and divided into acyanotic and cyanotic group. RSO 2 in the brain, intestine, and kidney was measured us- ing near-infrared spectroscopy (NIRS). Simultaneously, heart rate (HR), breathing frequency (BF), mean arterial blood pressure (MAP), and arterial oxygen saturation (Sa o 2 ) were recorded. Results Newborns with CHD had significantly lower rSO 2 in the left brain hemisphere (67 +- 11% vs 76 +- 8%, P = 0.004), right brain hemisphere (68 +- 11% vs 77 +- 8%, P < 0.001), and the kidney (68 +- 13% vs 77 +- 10%, P = 0.015). RSO 2 in the intestine did not significantly differ between the groups. HR, MAP, and Sa o 2 also did not differ between the groups, whereas BF was significantly higher in the CHD group (57 +- 12 vs 39 +- 10 breaths/min, P < 0.001). Between cyanotic and acyanotic group, we found no significant dif- ferences in rSO 2 of any tissue. Conclusions Monitoring tissue oxygenation by NIRS could enable a timely detection of hemodynamically im- portant CHD.
Keywords     newborns
heart defects
tissue oxygenation
novorojenčki
srčne napake
oksigenacija tkiva