Author/Editor		Korošec, Peter; Gibbs, Bernhard F.; Rijavec, Matija; Custovic, Adnan; Turner, Paul J.
Title		Important and specific role for basophils in acute allergic reactions
Type		članek
Vol. and No.		Letnik 48, št. 5
Publication year		2018
Volume		str. 502-512
ISSN		0954-7894 - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Language		eng
Abstract		IgE-mediated allergic reactions involve the activation of effector cells, predominantly through the high-affinity IgE receptor (FceRI) on mast cells and basophils. Although the mast cell is considered the major effector cell during acute allergic reactions, more recent studies indicate a potentially important and specific role for basophils and their migration which occurs rapidly upon allergen challenge in humans undergoing anaphylaxis. We review the evidence for a role of basophils in contributing to clinical symptoms of anaphylaxis, and discuss the possibility that basophil trafficking during anaphylaxis might be a pathogenic (to target organs) or protective (preventing degranulation in circulation) response. Finally, we examine the potential role of basophils in asthma exacerbations. Understanding the factors that regulate basophil trafficking and activation might lead to new diagnostic and therapeutic strategies in anaphylaxis and asthma.
Descriptors		Allergy and immunology Basophils Anaphylaxis Alergija in imunologija Bazofilci Anafilaksija