Author/Editor		Vander Poorten, Vincent; Triantafyllou, Asterios; Skálová, Alena; Stenman, Göran; Bishop, Justin A.; Hauben, Esther; Hunt, Jennifer L.; Hellquist, Henrik; Feys, Simon; Strojan, Primož
Title		Polymorphous adenocarcinoma of the salivary glands
Type		članek
Vol. and No.		Letnik 275, št. 7
Publication year		2018
Volume		str. str. 1681-1695
ISSN		0937-4477 - European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Language		eng
Abstract		Although relatively rare, polymorphous adenocarcinoma (PAC) is likely the second most common malignancy of the minor salivary glands (MiSG). The diagnosis is mainly based on an incisional biopsy. The optimal treatment comprises wide surgical excision, often with adjuvant radiotherapy. In general, PAC has a good prognosis. Previously, PAC was referred to as polymorphous low-grade adenocarcinoma (PLGA), but the new WHO classification of salivary gland tumours has also included under the PAC subheading, the so-called cribriform adenocarcinoma of minor salivary glands (CAMSG). This approach raised controversy, predominantly because of possible differences in clinical behaviour. For example, PLGA (PAC, classical variant) only rarely metastasizes, whereas CAMSG often shows metastases to the neck lymph nodes. Given the controversy, this review reappraises the definition, epidemiology, clinical presentation, diagnostic work-up, genetics, treatment modalities, and prognosis of PAC of the salivary glands with a particular focus on contrasting differences with CAMSG.
Keywords		polimorfni adenokarcinom adenokarcinom patologija žleze slinavke polymorphous adenocarcinoma adenocarcinoma pathology salivary glands