Author/Editor | Knific, Tamara; Vouk, Katja; Vogler, Andrej; Osredkar, Joško; Gstöttner, Manuela; Wenzl, René; Lanišnik-Rižner, Tea | |
Title | Models including serum CA-125, BMI, cyst pathology, dysmenorrhea or dyspareunia for diagnosis of endometriosis | |
Type | članek | |
Publication year | 2018 | |
Volume | str. str. | |
ISSN | 1752-0363 - Biomarkers in medicine | |
Language | eng | |
Abstract | Aim: To evaluate preoperative levels of CA-125 and HE4 in patients with endometriosis-like symptoms and to construct diagnostic models. Patients: Prospective case%control study included 124 endometriosis patients and 97 control patients. Materials & methods: Logistic regression was used to construct diagnostic models based on serum biomarker levels and clinical data. Results: A model with CA-125, BMI, information on cysts and dyspareunia had an area under the curve value of 0.836, sensitivity of 74.0% and specificity of 81.3%. The second model included CA-125, BMI, information on cysts and dysmenorrhea and had an area under the curve value of 0.819, sensitivity of 74.8% and specificity of 79.2%. Conclusion: Constructed models have the potential for noninvasive diagnosis of endometriosis, and might be translated into clinical practice after additional validation. | |
Keywords | endometrioza ciste jajčnikov CA-125 endometriosis ovarian cysts CA-125 |