Author/Editor     Zalar, Bojan; Haslberger, Alexander G.; Peterlin, Borut
Title     The role of microbiota in depression - a brief review
Type     članek
Vol. and No.     Letnik 30, št. 2
Publication year     2018
Volume     str. 136-141
ISSN     0353-5053 - Psychiatria Danubina
Language     eng
Abstract     The microbiota-gut-brain axis is a bidirectional homeostatic route of communication between both of the organs direct via receptors of the CNS or via epigenetic mechanisms of divers metabolites e.g. SCFA, GABA, [beta] -hydroxybutyrate. Thus, a modulation of gut microbiota via nutrition, lifestyle etc. might be effective for emotional status and depressive disorders. The dietary composition has an influence on gut microbiota composition, microbial metabolite profile and the according consequences on emotional status and depression within a system biologic approach. There are changes in gut microbiota composition and gut microbial profile (butyrate, GABA, [beta] -hydroxybutyrate) effecting epigenetic regulation (histone acetylation, DNA methylation) and gene expression of receptors and mediators (SLC6A4, BDNF, GABA, GPRs) involved in depressive disorders.
Keywords     microbiota
depression
receptors of the CNS
mikrobiota
depresija
CNS receptorji