Author/Editor		Skubic, Cene; Drakulić, Živa; Rozman, Damjana
Title		Personalized therapy when tackling nonalcoholic fatty liver disease
Type		članek
Vol. and No.		Letnik 14, št. 8
Publication year		2018
Volume		str. 831-841
ISSN		1742-5255 - Expert opinion on drug metabolism & toxicology
Language		eng
Abstract		Nonalcoholic fatty liver disease (NAFLD) is the most frequent liver disease in the world. It describes a term for a group of hepatic diseases including steatosis, fibrosis, and cirrhosis that can finally lead to hepatocellular carcinoma. There are many factors influencing NAFLD initiation and progression, such as obesity, dyslipidemia, insulin resistance, genetic factors, and hormonal changes. However, there is also lean-NAFLD which is not associated with obesity. NAFLD is considered to be a sexually dimorphic disease. In most cases, men have a higher prevalence for the disease compared to premenopausal women. Areas covered: In this review, we first summarize the NAFLD disease epidemiology, pathology, and diagnosis. We describe NAFLD progression with the focus on sexual and genetic differences for disease development and pharmacological treatment. Personalized treatment for multifactorial NAFLD is discussed in consideration of different factors, including genetics, gender and sex. Expert opinion: The livers of female and male NAFLD patients have different metabolic capacities which influence the metabolism of all drugs applied to such patients. This aspect is not yet sufficiently taken into account. The liver computational models might quicken the pace toward assessing personalized disease progression and treatment options.
Keywords		nonalcoholic fatty liver drug metabolism hormonal differences brezalkoholna maščobna jetra presnova zdravil hormonske razlike