| Author/Editor | Kojc, Nika; Perše, Martina; Pleško, Jerica; Večerić-Haler, Željka | |
| Title | Early graft loss after kidney transplantation | |
| Type | članek | |
| Vol. and No. | , št. Vol. 2018 | |
| Publication year | 2018 | |
| Volume | str. [1]-8 | |
| ISSN | 2314-6141 - BioMed research international | |
| Language | eng | |
| Abstract | Decision process about the acceptance of the deceased donor kidney for transplantationmight be challenging.Although histological evaluation of pretransplant donor kidney biopsy provides reliable information regarding cortical necrosis, vascular thrombosis, extensive global glomerulosclerosis, and interstitial fibrosis/tubular atrophy, only electron microscopy enables thorough and reliable insights into microvasculature changes of kidney graft. The aim of the present paper is to briefly present two cases of early kidney graft loss. In one case, the donor was exposed to long-term extracorporeal membrane oxygenation (ECMO); in the other case, the donor experienced Takotsubo cardiomyopathy. In both cases, light microscopy of pretransplant biopsy found no pathology or significant discrepancy in morphology of kidney graft, while electronmicroscopy revealed severe endothelial dysfunction of renal microvasculature.Our results suggest that severe injury of renalmicrovasculaturewith relatively preserved tubular epitheliummay be associated with some conditions of deceased kidney donors leading to early kidney graft nonfunction and loss. Further studies are needed to determine prognostic significance of severe ultrastructural microvasculature lesions and to evaluate disease states and conditions that could be associated with severe endothelial dysfunction of kidney graft. | |
| Keywords | kidney transplantation renal microvasculature endothelial dysfunction presaditev ledvice ledvična mikrovaskulatura endotelna disfunkcija |