Author/Editor		Kuret, Tadeja; Burja, Blaž; Feichtinger, Julia; Thallinger, Gerhard G.; Frank Bertoncelj, Mojca; Lakota, Katja; Žigon, Polona; Sodin-Šemrl, Snežna; Čučnik, Saša; Tomšič, Matija; Hočevar, Alojzija
Title		Gene and miRNA expression in giant cell arteritis-a concise systematic review of significantly modified studies
Type		članek
Publication year		2018
Volume		str. str.
ISSN		0770-3198 - Clinical rheumatology
Language		eng
Abstract		Giant cell arteritis (GCA) is a systemic vasculitis in individuals older than 50 years, characterized by headaches, visual distur- bances, painful scalp, jaw claudication, impairment of limb arteries, and systemic inflammation, among other symptoms. GCA diagnosis is confirmed by a positive temporal artery biopsy (TAB) or by imaging modalities. A prominent acute phase response with inflammation is the hallmark of the disease, predominantly targeting large- and medium-sized arteries leading to stenosis or occlusion of arterial lumen. To date, there are no reliable tissue markers specific for GCA. Scarce reports have indicated the importance of epigenetics in GCA. The current systematic review reports significantly changed candidate biomarkers in TABs of GCA patients compared to non-GCA patients using qPCR.
Keywords		gene and miRNA expression giant cell arteritis modified studies genska in miRNA ekspresija velikanski arteritis spremenjene študije