| Author/Editor | Miljković, Milica; Stefanović, Aleksandra; Bogavac-Stanojević, Nataša; Simić-Ogrizović, Sanja; Dumić, Jerka; Černe, Darko; Jelić-Ivanović, Zorana; Kotur Stevuljević, Jelena | |
| Title | Association of pentraxin-3, galectin-3 and matrix metalloproteinase-9/timp-1 with cardiovascular risk in renal disease patients | |
| Type | članek | |
| Vol. and No. | Letnik 56, št. 4 | |
| Publication year | 2017 | |
| Volume | str. 673-680 | |
| ISSN | 0353-9466 - Acta clinica Croatica | |
| Language | eng | |
| Abstract | Inflammation, apoptosis and extracellular remodeling play significant roles in cardiovascular disease (CVD) underlying the major causes of mortality in renal patients. In 19 pre-dialysis patients, 21 dialysis patients and 20 control subjects, the concentrations of pentraxin-3, galectin-3, MMP-9 and TIMP-1 were determined by ELISA. CVD risk was calculated according to the Framingham risk score algorithm. Pentraxin-3 was increased in renal patients compared to healthy controls (p<0.001). In contrast, galectin-3 was reduced in hemodialysis patients compared to pre-dialysis patients and controls (p<0.001). In addition, MMP-9 and TIMP-1 were elevated in renal patients compared to controls (p<0.01 and p<0.001, respectively). Logistic regression analyses disclosed associations of galectin-3, MMP-9, pentraxin-3 and glomerular filtration with calculated CVD risk score. Combined testing of pentraxin-3, galectin-3, MMP-9 and glomerular filtration rate can discriminate renal patients with high and low risk of a coronary event.Upala, apoptoza i remodeliranje ekstracelularnog matriksa igraju značajnu ulogu u razvoju kardiovaskularnih bolesti (KVB) koje su glavni uzrok smrtnosti kod bubrežnih bolesnika. Kod 19 prijedijaliznih i 21 dijaliznog bolesnika, kao i kod 20 zdravih kontrolnih osoba koncentracije pentraksina-3, galektina-3, MMP-9 i TIMP-1 određene su pomoću tehnike ELI-SA. Rizik od KVB izračunat je prema Framinghamskom algoritamu. Pentraksin-3 je bio povećan kod bubrežnih bolesnika u usporedbi sa zdravim kontrolama (p<0,001). Nasuprot tome, galektin-3 je bio smanjen kod bolesnika na hemodijalizi u %odnosu na predijalizne bolesnike i kontrole (p<0,001). Uz to, vrijednosti MMP-9 i TIMP-1 su bile povišene kod bubrežnih bolesnika u usporedbi s kontrolama (p<0,01 i p<0,001). Logističke regresijske analize pokazale su povezanost udruženih galektina-3, MMP-9, pentraksina-3 i glomerularne filtracije s izračunatim rezultatom rizika od KVB. Kombinirana ispi-ti%vanja pentraksina-3, galektina-3, MMP-9 i glomerularne filtracije mogla bi razlikovati bubrežne bolesnike s visokim i niskim rizikom od koronarnog događaja. | |
| Descriptors | Ledvice | |
| Keywords | ledvične bolezni pentraksin 3 galektin3 matriksna metaloproteinaza 9 tkivni inhibitor matriksne metaloproteinaze 1 kardiovaskularne bolezni |