| Author/Editor | Žigon, Polona; Podovšovnik, Anuška; Ambrožič, Aleš; Tomšič, Matija; Hočevar, Alojzija; Gašperšič, Nataša; Rotar, Žiga; Praprotnik, Sonja; Sodin-Šemrl, Snežna; Čučnik, Saša | |
| Title | Added value of non-criteria antiphospholipid antibodies for antiphospholipid syndrome | |
| Type | članek | |
| Publication year | 2018 | |
| Volume | str. str. | |
| ISSN | 0770-3198 - Clinical rheumatology | |
| Language | eng | |
| Abstract | The international classification criteria for definite antiphospholipid syndrome (APS) include three laboratory measurements: lupus anticoagulant (LA), IgG and IgM isotypes of anti-cardiolipin (aCL) and anti-[beta]2glycoprotein I antibodies (anti-[beta]2GPI). When persistently elevated, they are specific for APS; however, many patients that fulfil clinical criteria may exhibit negative serological results. These seronegative APS (SN-APS) are exposed to an increased thrombotic risk. The aims of our cross-sectional, retrospective study of consecutive autoimmune patients' samples were to evaluate the association of non-criteria antiphospholipid antibodies (aPL) with thrombosis and obstetric events, to calculate the risk score for adverse events and to assess the specific contribution of single aPL positivity in SN-APS. LA, aCL, anti-[beta]2GPI and anti-phosphatidylserine/prothrombin antibodies (aPS/PT) of IgG, IgM, and IgA isotypes were determined in sera of 323 patients with autoimmune disorders. Medical records of all patients were carefully analyzed. aCL, anti-[beta]2GPI and aPS/PT of IgG and IgA isotypes were significantly associated with thrombosis while none of the IgM aPL showed such association. aPS/PT of all isotypes, aCL and anti-[beta]2GPI of IgG and IgA isotype showed significant correlation to obstetric events. When considering results of aPS/PT ELISA, we could additionally identify 3% of thrombotic patients and 2% of obstetric patients. Thrombotic and obstetric risk scores were calculated showing significantly higher association to clinical events, as compared to evaluating individual risk factors. aPS/PT could represent an additional biomarker in SN-APS patients. IgA aPL are associated with thrombosis and obstetric complications. Risk scores accounting different aPL and conventional risk factors, better assesses risk for adverse event, as compared to evaluating individual factors alone. | |
| Keywords | antiphospholipid antibodies antiphospholipid syndrome thrombosis antifosfolipidna protitelesa antifosfolipidni sindrom tromboza |