Author/Editor		Shan, Ling; Bao, Ai-Min; Swaab, Dick Frans
Title		The human histaminergic system in neuropsychiatric disorders
Type		članek
Vol. and No.		Letnik 38, št. 3
Publication year		2015
Volume		str. 167-177
ISSN		0166-2236 - Trends in Neurosciences
Language		eng
Abstract		Histaminergic neurons are exclusively located in the hypothalamic tuberomamillary nucleus, from where they project to many brain areas. The histaminergic system is involved in basic physiological functions, such as the sleep-wake cycle, energy and endocrine homeostasis, sensory and motor functions, cognition, and attention, which are all severely affected in neuropsychiatric disorders. Here, we present recent postmortem findings on the alterations in this system in neuropsychiatric disorders, including Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), depression, and narcolepsy. In addition, we highlight the need to validate animal models for these diseases and also for Tourette's syndrome (TS) in relation to alterations in the histaminergic system. Moreover, we discuss the potential for, and concerns over, the use of novel histamine 3 receptor (H3R) antagonists/inverse agonists as treatment for such disorders.
Keywords		Parkinson's disease Alzheimer's disease narcolepsy Parkinsonova bolezen Alzheimerjeva bolezen narkolepsija