Author/Editor		Kristanc, Luka; Božič, Bojan; Zemljič Jokhadar, Špela; Sollner Dolenc, Marija; Gomišček, Gregor
Title		The pore-forming action of polyenes
Type		članek
Vol. and No.		Letnik 1861, št. 1
Publication year		2019
Volume		str. 418-430
ISSN		0005-2736 - Biochimica et biophysica acta - Biomembranes
Language		eng
Abstract		The incidence of resistant fungal pathogens has been increasing, especially in immuno-compromised people. As such, considerable research has been focused on discovering anti-fungal agents with new mechanisms of action and on optimizing the use of existing agents. In this context, interest in the polyene group of anti-fungals has recently been renewed, since they are known to be effective against a broad spectrum of fungal pathogens that only rarely develop a resistance to them. In the past 10 years considerable efforts have been made to improve their efficacy and, simultaneously, to reduce their toxicity. Knowledge about the basic mechanisms of their action will be of crucial importance to further optimizing their use. The mechanisms of polyene action at the membrane level are reviewed here, focusing primarily on their pore-forming activity and on the resulting osmotic responses of artificial lipid vesicles and different eukaryotic cells.
Keywords		polyenes sterols osmotic stress polieni steroli osmotski stres