Author/Editor		Eikelboom, John W.; Kozek-Langenecker, S.; Exadaktylos, A.; Batorova, A.; Boda, Z.; Christory, F.; Gornik, I.; Kekstas, Gintautas; Kher, André; Komadina, Radko
Title		Emergency care of patients receiving non-vitamin K antagonist oral antocoagulants
Type		članek
Vol. and No.		Letnik 120, št. 4
Publication year		2018
Volume		str. 645-656
ISSN		0007-0912 - British Journal of Anaesthesia
Language		eng
Abstract		Non-vitamin K antagonist oral anticoagulants (NOACs), which inhibit thrombin (dabigatran) and factor Xa (rivaroxaban, apixaban, edoxaban) have been introduced in several clinical indications. Although NOACs have a favourable benefit-risk profile and can be used without routine laboratory monitoring, they are associated - as any anticoagulant - with a risk of bleeding. In addition, treatment may need to be interrupted in patients who need surgery or other procedures. The objective of this article, developed by a multidisciplinary panel of experts in thrombosis and haemostasis, is to provide an update on the management of NOAC-treated patients who experience a bleeding episode or require an urgent procedure. Recent advances in the development of targeted reversal agents are expected to help streamline the management of NOAC-treated patients in whom rapid reversal of anticoagulation is required.
Descriptors		Anticoagulants Hemorrhage Hemorrhage Antikoagulanti Krvavitve Krvavitve Adverse effects Chemically induced Therapy Škodljivi učinki Kemično inducirane Zdravljenje