Author/Editor		Keber, Tajda; Tretjak, Martin; Cokan Vujkovac, Andreja; Mravljak, Marija; Ravber, Katja; Vujkovac, Bojan
Title		Paricalcitol as an antiproteinuric agent can result in the deterioration of renal and heart function in a patient with Fabry disease
Type		članek
Vol. and No.		, št. Vol. 18
Publication year		2017
Volume		str. 644-648
ISSN		1941-5923 - The American journal of case reports
Language		eng
Abstract		BACKGROUND: Fabry disease is a rare and progressive X-linked inherited disorder of glycosphingolipid metabolism that is due to deficient or absent lysosomal a-galactosidase A activity. Among its other associated signs and symptoms, patients present with renal failure and proteinuria, which are markers of disease progression. Renin-angiotensin-aldosterone system (RAAS) blockers can slow the progression of chronic renal failure and proteinuria. In fact, some studies have shown the beneficial effects of paricalcitol on proteinuria. CASE REPORT: We present a case of a female patient with the classic variant of Fabry disease. She was treated with a high dose of paricalcitol as an antiproteinuric agent due to unsatisfactory double-RAAS blockage, which resulted in transient worsening of cardiac and renal function. CONCLUSIONS: Despite the positive effects of paricalcitol as an antiproteinuric agent, as previously shown by some authors, our case highlights the possible serious adverse effects associated with the use of high doses of this drug.
Descriptors		Genetic diseases Genetske bolezni Fabry disease Fabryjeva bolezen
Keywords		25-Hydroxyvitamin D 2 heart failure proteinuria renal insufficiency 25-Hydroxyvitamin D 2 srčna okvara proteinurija renalna insuficienca