Author/Editor     Seiwerth, Sven; Brcic, Luka; Batelja Vuletic, Lovorka; Kolenc, Danijela; Aralica, Gorana; Misic, Marija; Zenko Sever, Anita; Drmić, Domagoj; Ručman, Rudolf; Sikirić, Predrag
Title     BPC 157 and blood vessels
Type     članek
Vol. and No.     Letnik iss. 7, št. Vol. 20
Publication year     2014
Volume     str. 1121-1125
ISSN     1381-6128 - Current pharmaceutical design
Language     eng
Abstract     This review focuses on the described effects of BPC 157 on blood vessels after different types of damage, and elucidate by investigating different aspects of vascular response to injury (endothelium damage, clotting, thrombosis, vasoconstriction, vasodilatation, vasculoneogenesis and edema formation) especially in connection to the healing processes. In this respect, BPC 157 was concluded to be the most potent angiomodulatory agent, acting through different vasoactive pathways and systems (e.g. NO, VEGF, FAK) and leading to optimization of the vascular response followed, as it has to be expected, by optimization of the healing process. Formation of new blood vessels involves two main, partly overlapping mechanisms, angiogenesis and vasculogenesis. The additional mechanism of arteriogenesis is involved in the formation of collaterals. In conjunction with blood vessel function, we at least have to consider leakage of fluid/proteins/plasma, resulting in edema/exudate formation as well as thrombogenesis. Blood vessels are also strongly involved in tumor biology. In this aspect, we have neoangiogenesis resulting in pathological vascularization, vascular invasion resulting in release of metastatic cells and the phenomenon of homing resulting in formation of secondary tumors - metastases.
Keywords     vasculogenesis
angiogenesis
primary development
vaskulogeneza
angiogeneza
primarni razvoj