Author/Editor		Sikirić, Predrag; Seiwerth, Sven; Ručman, Rudolf; Turkovic, Branko; Stancic-Rokotov, Dinko; Brcic, Luka; Sever, Marko; Klicek, Robert; Radic, Bozo; Kolenc, Danijela
Title		Focus on ulcerative colitis
Type		članek
Vol. and No.		Letnik iss. 1, št. Vol. 19
Publication year		2012
Volume		str. 126-132
ISSN		0929-8673 - Current medicinal chemistry
Language		eng
Abstract		Stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W. 1419) may be the new drug stable in human gastric juice, effective both in the upper and lower GI tract, and free of side effects. BPC 157, in addition to an antiulcer effect efficient in therapy of inflammatory bowel disease (IBD) (PL 14736) so far only tested in clinical phase II, has a very safe profile, and exhibited a particular wound healing effect. It also has shown to interact with the NO-system, providing endothelium protection and angiogenic effect, even in severely impaired conditions (i.e., it stimulated expression of early growth response 1 gene responsible for cytokine and growth factor generation and early extracellular matrix (collagen) formation (but also its repressor nerve growth factor 1- A binding protein-2)), important to counteract severe complications of advanced and poorly controlled IBD. Hopefully, the lessons from animal studies, particularly advanced intestinal anastomosis healing, reversed short bowel syndrome and fistula healing indicate BPC 157s high significance in further IBD therapy. Also, this supportive evidence (i.e., no toxic effect, limit test negative, LD1 not achieved, no side effect in trials) may counteract the problems commonly exercised in the use of peptidergic agents, particularly those used on a long-term basis.
Keywords		BPC 157 intestinal anastomosis inflammatory bowel disease BPC 157 intestinalna anastomoza vnetna črevesna bolezen