| Author/Editor | Plemeniti Tololeski, Barbara; Debeljak, Maruša; Perković-Benedik, Mirjana; Rigler, Tristan; Kyriakopoulos, Marinos; Kotnik, Primož; Šurlan Popović, Katarina; Drobnič Radobuljac, Maja | |
| Title | The use of quetiapine in treatment of acutepsychotic symptoms in an adolescentpatient with primary brain calcification | |
| Type | članek | |
| Vol. and No. | Letnik 19, št. 1 | |
| Publication year | 2019 | |
| Volume | str. 1-5 | |
| ISSN | 1471-244X - BMC psychiatry | |
| Language | eng | |
| Abstract | Background:Primary brain calcification (PBC), a neurodegenerative disorder with characteristic calcium depositsin the basal ganglia and other brain areas, typically presents with various neurological and psychiatric symptomsin the fourth or fifth decade of life or later. We present the case of a patient with psychiatric manifestations muchearlier than usual, in the second decade of life.Case presentation:The case of an adolescent female with acute psychotic symptoms, emotional instability,disorganized and suicidal behavior, stereotypical movements, below average intelligence and a three-yearhistory of headaches is reported. Among others, the presentation included tactile hallucinations with secondaryhypochondriacal delusions, which are rarely described in this diagnosis. Massive calcinations in the area of thebasal ganglia and thalamus were determined by computerized tomography. Other causes of brain calcificationwere excluded. No causative mutations were found inselected genes. All the symptoms apart from lowerintellectual abilities improved with quetiapine and sertraline. The patient showed no side effects.Conclusions:This case report highlights the successful use of quetiapine for symptomatic treatment ofacute psychosis due to PBC in an adolescent without exacerbating extrapyramidal symptoms. | |
| Keywords | akutna psihoza mladostnik primarna kalcifikacija možganov acute psychosis adolescent primary brain calcification |