Author/Editor		Šenk, Barbara; Goričar, Katja; Kovač, Viljem; Dolžan, Vita; Franko, Alenka
Title		Genetic polymorphisms in aquaporin 1 as risk factors for malignant mesothelioma and biomarkers of response to cisplatin treatment
Type		članek
Vol. and No.		Letnik 53, št. 1
Publication year		2019
Volume		str. 96-104
ISSN		1318-2099 - Radiology and oncology
Language		eng
Abstract		Malignant mesothelioma (MM) is an asbestos related aggressive tumor with poor prognosis. The aim of this study was to investigate if aquaporin 1 (AQP1) genetic polymorphisms influence the risk of MM and the response to cisplatin based MM treatment. Patients and methods. The case-control study included 231 patients with MM and a control group of 316 healthy blood donors. All subjects were genotyped for three AQP1polymorphisms (rs1049305, rs1476597 and rs28362731). Logistic and Cox regression were used in statistical analysis. Results. AQP1 rs1049305 polymorphism was significantly associated with MM risk in dominant model adjusted for gender and age (OR = 0.60, 95% CI = 0.37%0.96, Padj = 0.033). This polymorphism was also significantly associated with cisplatin based treatment related anaemia (unadjusted: OR = 0.49, 95% CI = 0.27%0.90, P = 0.021; adjusted: for CRP: OR = 0.52, 95% CI = 0.27%0.99, P = 0.046), with leukopenia (OR = 2.09, 95% CI = 1.00%4.35, P = 0.049) in dominant model and with thrombocytopenia (OR = 3.06, 95% CI = 1.01%9.28, P = 0.048) and alopecia (OR = 2.92, 95% CI = 1.00%8.46, P = 0.049) in additive model. AQP1 rs28362731 was significantly associated with thrombocytopenia (unadjusted: OR = 3.73, 95% CI = 1.00%13.84, P = 0.049; adjusted for pain: OR = 4.63, 95% CI = 1.13%19.05, P = 0.034) in additive model. Conclusions. AQP1 may play a role in the risk of MM. Furthermore, AQP1 genotype information could improve the prediction of MM patients at increased risk for cisplatin toxicity.
Keywords		maligni mezoteliom genetski polimorfizem cisplatin biološki označevalci malignant mesothelioma genetic polymorphism cisplatin biomarkers