Author/Editor		Vidonja-Uzelac, Teodora; Tatalović, Nikola; Mijović, Milica; Nikolić-Kokić, Aleksandra; Oreščanin-Dušić, Zorana; Bresjanac, Mara; Blagojević, Duško
Title		Effects of ibogaine per os treatment on redox homeostasis in rat kidney
Type		članek
Publication year		2019
Volume		str. str.
ISSN		0354-4664 - Archives of biological sciences : [official journal of the Serbian Biological Society]
Language		eng
Abstract		Our previous results showed that a single oral dose (1 or 20 mg/kg body weight) of the anti-addiction agent ibogaine induced in rats 6 and 24 h after administration glycogenolytic activity in hepatocytes, followed by a mild oxidative stress. In this work, we examined the in vivo effect of the same doses of ibogaine on rat kidney morphology, antioxidant enzyme (superoxide dismutases (SOD 1 and 2), catalase, glutathione peroxidase (GSH-Px), glutathione reductase (GR) and glutathione-S-transferase) activities, and oxidative stress (TBARS) and redox (-SH groups) parameters. The dose of 1 mg/kg ibogaine induced an elevation in SOD1 activity and decreased GR activity after 6 and 24 h. GR activity was decreased at 6 and 24 h after 20 mg/kg ibogaine administration, suggesting changed redox homeostasis. After 24 h, we observed an increase in moderate morphological changes, without changes in urinalyses, indicating that kidney function was not measurably affected. Nevertheless, kidney-function monitoring during and following ibogaine use in human subjects is advisable. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no.173014: Molecular mechanisms of redox signaling in homeostasis, adaptation and pathology]
Keywords		ibogain ledvice antioksidativni encimi ibogaine kidney antioxidant enzymes