| Author/Editor | Ilić, Spomenko; Brcic, Iva; Mester, M.; Filipovic, Marinko; Sever, Marko; Klicek, Robert; Barisic, Ivan; Radic, Bozo; Zoričić, Zoran; Kolenc, Danijela | |
| Title | Over-dose insulin and stable gastric pentadecapeptide BPC 157. Attenuated gastric ulcers, seizures, brain lesions, hepatomegaly, fatty liver, breakdown of liver glycogen, profound hypoglycemia and calcification in rats | |
| Type | članek | |
| Source | In: 13th ICGR/ICUR - International Conference on Gastrointestinal Research, International Conference on Ulcer Research Meeting; 2009 Sep 10-16; Split Krakow : Polish physiological society | |
| Vol. and No. | Letnik 60, št. suppl. 60 | |
| Publication year | 2009 | |
| Volume | str. 67-70 | |
| Language | eng | |
| Abstract | We focused on over-dose insulin (250 IU/kg i.p.) induced gastric ulcers and then on other disturbances that were concomitantly induced in rats, seizures (eventually fatal), severely damaged neurons in cerebral cortex and hippocampus, hepatomegaly, fatty liver, increased AST, ALT and amylase serum values, breakdown of liver glycogen with profound hypoglycemia and calcification development. Calcium deposits were present in the blood vessel walls, hepatocytes sourrounding blood vessels and sometimes even in parenchyma of the liver mainly as linear and only occasionally as granular accumulation. As an antidote after insulin, we applied the stable gastric pentadecapeptide BPC 157 (10 %g/kg) given (i) intraperitoneally or (ii) intragastrically immediately after insulin. Controls received simultaneously an equivolume of saline (5 ml/kg). Those rats that survived till the 180 minutes after over-dose application were further assessed. Interestingly, pentadecapeptide BPC 157, as an antiulcer peptide, may besides stomach ulcer consistently counteract all insulin disturbances and fatal outcome. BPC 157 rats showed no fatal outcome, they were mostly without hypoglycemic seizures with apparently higher blood glucose levels (glycogen was still present in hepatocytes), less liver pathology (i.e., normal liver weight, less fatty liver), decreased ALT, AST and amylase serum values, markedly less damaged neurons in brain and they only occasionally had small gastric lesions. BPC 157 rats exhibited mostly only dot-like calcium presentation. In conclusion, the success of BPC 157 therapy may indicate a likely role of BPC 157 in insulin controlling and BPC 157 may influence one or more causative process(es) after excessive insulin application. | |
| Keywords | stable gastric pentadecapeptide BPC 157 insulin hepatomegaly stabilni želodčni pentadekapeptid BPC 157 insulin hepatomegalija |