Author/Editor		Marinko, Tanja
Title		Pericardial disease after breast cancer radiotherapy
Type		članek
Vol. and No.		Letnik 53, št. 1
Publication year		2019
Volume		str. 1-5
ISSN		1318-2099 - Radiology and oncology
Language		eng
Abstract		Breast cancer is the second most common cancer worldwide. Thanks to the modern oncological treatments, disease specific survival has improved throughout the last decades. The number of breast cancer survivors has been increasing, and more and more attention has been paid to the breast cancer treatment side effects. Whereas there are many data regarding ischemic heart disease after radiotherapy for breast cancer, there is not much data in the literature about the incidence and clinical meaning of pericardial disease after breast cancer radiotherapy. Conclusions. Although radiation-induced pericarditis is the earliest form of radiation-induced cardiovascular disease after irradiation of the heart, it seems that in clinical practice, especially by using modern radiotherapy treatment techniques, it is underdiagnosed because patients are mostly asymptomatic. In some cases, especially in its late form and after multimodal systemic oncological treatment in combination with radiotherapy, it could be presented in severe form and life threatening. Treatment modalities for radiation-induced pericardial diseases are the same as in the non-irradiated population, but in the irradiated patients, surgery may be difficult.Rak dojk je drugi najpogostejši rak na svetu. Moderni načini onkološkega zdravljenja izboljšujejo preživetje bolnic z rakom dojk in število tistih, ki so raka prebolele se povečuje. Vedno več pozornosti namenjamo ugotavljanju in spremljanju neželenih učinkov onkološkega zdravljenja. O ishemični bolezni srca, ki je lahko posledica zdravljenja raka dojk z obsevanjem, je objavljeno že veliko literature, nasprotno pa je o incidenci in kliničnem pomenu bolezni osrčnika po obsevanju malo podatkov. Zaključki. Čeprav je vnetje osrčnika najzgodnejša oblika bolezni srca, ki nastane po obsevanju v področju srca, je v klinični praksi malokrat prepoznano, saj večinoma poteka brez simptomov, še posebno ob uporabi modernih obsevalnih tehnik. V posameznih primerih, navadno v povezavi s sistemskim onkološkim zdravljenjem in pozno po zaključenem zdravljenju, se lahko razvije resna bolezen osrčnika, ki je lahko tudi življenjsko ogrožujoča. Načini zdravljenja so enaki kot za bolnike, ki niso bili zdravljeni z obsevanjem, vendar je kirurško zdravljenje pri obsevanih bolnikih lahko težje izvedljivo.
Keywords		bolezen osrčnika ishemična bolezen srca kardiološka onkologija rak dojke obsevanje pericardial disease cardiotoxicity cardio-oncology breast cancer radiotherapy