Author/Editor		Knežević, Anamarija; Vinković, Vladimir; Maraković, Nikola; Šinko, Goran
Title		Enzyme-catalyzed cascade synthesis of hydroxyiminoacetamides
Type		članek
Vol. and No.		Letnik 55, št. 31
Publication year		2014
Volume		str. 4338-4341
ISSN		0040-4039 - Tetrahedron letters
Language		eng
Abstract		In order to synthesize N-(3-azido-1-phenylpropyl)-2-hydroxyiminoacetamide, a key compound for the preparation of acetylcholinesterase (AChE) reactivators of the N-substituted 2-hydroxyiminoacetamide type, it was necessary to develop a method for forming an amide bond between an ethyl glyoxylate oxime and an amine. Using Candida antarctica lipase B (CAL-B) in a cascade enzyme-BOP catalyzed reaction, the efficient synthesis of the target hydroxyiminoacetamide was achieved.
Keywords		chemoenzimatska sinteza nastajanje amida encimska kataliza chemoenzymatic synthesis amide formation enzyme catalysis