Author/Editor		Fabjan, Andrej; Bajrović, Fajko
Title		Novel direct anticoagulants and atherosclerosis
Type		članek
Vol. and No.		Letnik 17, št. 1
Publication year		2019
Volume		str. 29-34
ISSN		1570-1611 - Current vascular pharmacology
Language		eng
Abstract		Coagulation factors can affect cellular processes that include inflammatory signaling by acting on endothelial protease activated receptors, vascular smooth muscle and inflammatory cells beyond the coagulation cascade. This is important in the pathogenesis of atherosclerosis. Accordingly, experimental data points to beneficial effects of coagulation protease inhibitors on the attenuation of atherosclerosis progression in animal models. However, available clinical data do not support the use of anticoagulants as an add-on treatment of atherosclerosis. New clinical studies are needed with a better selection of patients to clarify the role of novel direct anticoagulants in the management of atherosclerosis.
Keywords		atherosclerosis activated factor X coagulation factors ateroskleroza aktivirani faktor X koagulacijski faktorji