| Author/Editor | Zorc-Pleskovič, Ruda; Pleskovič, Aleš; Vraspir-Porenta, Olga; Zorc, Marjeta; Milutinović Živin, Aleksandra | |
| Title | Immune cells and vasa vasorum in the tunica media of atherosclerotic coronary arteries | |
| Type | članek | |
| Vol. and No. | Letnik 18, št. 3 | |
| Publication year | 2018 | |
| Volume | str. 240-245 | |
| ISSN | 1512-8601 - Bosnian journal of basic medical sciences / Udruženje bazičnih medicinskih znanosti = Association of Basic Medical Sciences | |
| Language | eng | |
| Abstract | In coronary artery disease (CAD), the disruption of the tunica media immune privilege manifests as increased leukocyte infiltration and the formation of vasa vasorum. We aimed to characterize the immune privilege status of the tunica media in human coronary arteries (CAs) with atherosclerotic plaques, by comparing the abundance and composition of immune-cell infiltrates within the individual arterial-wall layers, and by evaluating vasa vasorum neovascularization of the tunica media. The tissue samples were obtained from 36 symptomatic patients with diffuse CAD (aged 60-72 years) who underwent coronary endarterectomy. T and B cells, macrophages and endothelial cells in the CAs were detected by immunohistochemistry. Morphological analysis of CAs showed significant atherosclerotic changes in all specimens. In the media, we observed damage and loss of smooth muscle cells, destruction of the extracellular matrix architecture, and fibrosis. There were 43.3% of immune cells in the intima, 50% in the adventitia, and 6.7% in the media. In the media, 51.1% of the immune cells were T cells (p % 0.001 compared to B cells and macrophages; ANOVA, Scheffe post hoc analysis), 23.5% were B cells, and 25.4% were macrophages. The number of vasa vasorum in the media was 1 in 38.9% of CAs, 2-3 in 36.1%, and %4 in 25% of CAs. Our results indicate that, in atherosclerotic CAs, the immune privilege of the media is disrupted by the infiltration of T and B cells, macrophages, and the presence of vasa vasorum. | |
| Keywords | arterioskleroza koronarne arterije tunika medija T celice atherosclerosis coronary arteries tunica media T cells |