Author/Editor		Cvetinović, Nataša; Šekularac, Nikola; Haehling, Stephan; Tahirović, Elvis; Inkrot, Simone; Lainščak, Mitja; Apostolović, Svetlana; Putniković, Biljana; Waagstein, Finn; Gelbrich, Götz
Title		The [beta]-blocker uptitration in elderly with heart failure regarding biomarker levels
Type		članek
Vol. and No.		Letnik 12, št. 11
Publication year		2018
Volume		str. 1261-1270
ISSN		1752-0363 - Biomarkers in medicine
Language		eng
Abstract		: We investigated if the baseline value of mid-regional pro-atrial natriuretic peptide (NP), N-terminal pro-B-type NP and copeptin may be helpful in optimizing %-blocker uptitration in elderly patients with heart failure. PATIENTS & METHODS: According to the biomarkers' levels, 457 patients were divided into three subgroups and compared with each other at baseline and 3 months after. RESULTS: All mid-regional pro-atrial NP and N-terminal pro-B-type NP subgroups had significant amelioration of left ventricle ejection fraction and New York Heart Association (NYHA) class after 3 months of %-blocker uptitration (p < 0.001). More prominent improvement of left ventricle ejection fraction and New York Heart Association class was observed in subgroups with lower versus higher NPs levels. CONCLUSION: NPs levels, unlike copeptin levels, might be useful tool for objective selection of elderly heart failure patients who could have the greatest benefit of forced uptitration.
Keywords		kronično srčno popuščanje atrijski natriuretski peptid beta antagonist chronic heart failure pro-atrial natriuretic peptide