| Author/Editor | Kralik, Magdalena; Bon, Jurij | |
| Title | Revealing mechanisms of action of rTMS depression treatment | |
| Type | monografija | |
| Place | Vienna | |
| Publisher | [M. Kralik] | |
| Publication year | 2018 | |
| Volume | str. V, 97 str. | |
| Language | eng | |
| Abstract | Background: As EMG studies on the effect Theta Burst Stimulation (TBS) show inconclusive results, the combination of transcranial magnetic stimulation (TMS) and electroencephalography (EEG) opens up new possibilities to investigating TBS-effects on a cortical level. Especially, understanding mechanism of action of consecutively applied TBS as it is used in therapeutic settings is of importance as it might contribute to improving efficiency in therapeutic settings. Objective: The study uses intermittent TBS (iTBS), a putatively excitatory protocol, for stimulation and aims to investigate whether the 5 day consecutive administration of iTBS over the primary motor cortex induces cumulative changes in TMS-evoked potentials (TEPs) observable in EEG compared with sham stimulation. Furthermore, the relationship between motor-evoked (MEPs) and TEPs will be assessed. Methods: 10 healthy participants underwent 5 consecutive days of iTBS intervention, while another 10 healthy participants received 5 consecutive days of sham stimulation. Each day, cortical excitability was assessed before iTBS or sham intervention (baseline) and after the intervention while EEG was recorded. Results: Neither in MEPs nor in TEPs the anticipated facilitation after iTBS intervention was observable. Results of the iTBS and sham group showed similar results. Moreover, no clear relation between MEPs and TEPs was found. Conclusions: The effect of iTBS seems not be as straight-forward as anticipated. Yet, the effectiveness of iTBS in patient population is uncontested. Therefore, further research is needed to answer still open questions about the mechanisms of action of iTBS and to reveal the differences between treatment-responders and non-responders. Regarding TMS-EEGmethodology, methodological standardization is still pending and crucially necessary to validate and make results of TMS-EEG-studies comparable. | |
| Keywords | repetitivna transkranialna magnetna stimulacija stimulacija s theta izbruhi dnevno zaporedno stimuliranje repetitive magnetic stimulation theta burst stimulation daily consecutive application |