Author/Editor		Zottel, Alja; Videtič Paska, Alja; Jovchevska, Ivana
Title		Nanotechnology meets oncology
Type		članek
Vol. and No.		Letnik 12, št. 10
Publication year		2019
Volume		str. 1-28
ISSN		1996-1944 - Materials
Language		eng
Abstract		Advances in technology of the past decades led to development of new nanometer scale diagnosis and treatment approaches in cancer medicine leading to establishment of nanooncology. Inorganic and organic nanomaterials have been shown to improve bioimaging techniques and targeted drug delivery systems. Their favorable physico-chemical characteristics, like small sizes, large surface area compared to volume, specific structural characteristics, and possibility to attach different molecules on their surface transform them into excellent transport vehicles able to cross cell and/or tissue barriers, including the blood-brain barrier. The latter is one of the greatest challenges in diagnosis and treatment of brain cancers. Application of nanomaterials can prolong the circulation time of the drugs and contrasting agents in the brain, posing an excellent opportunity for advancing the treatment of the most aggressive form of the brain cancer-glioblastomas. However, possible unwanted side-effects and toxicity issues must be considered before final clinical translation of nanoparticles.
Keywords		nanomateriali rak možganov nanomedicina nanomaterials brain cancer nanomedicine