| Author/Editor | Cör, Andrej | |
| Title | Histological characteristics of periprosthetic tissue around metal on metal hip prostheses | |
| Type | članek | |
| Vol. and No. | Letnik 3, št. 1 | |
| Publication year | 2019 | |
| Volume | str. 33-36 | |
| ISSN | 2574-9927 | |
| Language | eng | |
| Abstract | Background: The most noteworthy advantage of metal-on-metal (MoM) total hip prostheses is low were rate and avoidance of polyethylene (PE) particles. The aim of the present study was to evaluate the histological characteristics of the tissue around MoM THR and to determine if perivascular lymphoid aggregates are characteristic findings in periprosthetic tissue around MoM prostheses. Material and methods: Tissue samples from 26 revised THRs with MoM articulation and 36 samples from two control groups: metal on polyethylene (MoPE) and ceramic on polyethylene (AloPE) were analysed. Histopathological and immunohistochemical analyses of periprosthetic tissue samples were performed in order to determine general cellular features. Semi-quantitave rating method to classify the numbers of macrophages, giant cells, lymphocytes, as well as extend of necrosis was used. In the second part of the study tissue form 544 consecutive THRs were analysed and cases with Oxford ALVAL scoring system 2+ and 3+ were selected regardless the type of prosthesis. Results: The retrieved periprosthetic tissue showed granulomtous tissue with varying numbers of macrophages with different cytoplasmatic amount of metal particles. The characteristic histological features in periprosthetic tissue from MoM THRs were diffuse lymphocytes in 16 (62%) of cases and perivascular lymphocytic cuffs in 15 (58%) cases. In comparison with tissue from control groups the lymphocytic infiltration in tissue around MoM THRs was much more intense and the presence of foreign body type giant cells was much less marked. In second part of the study we found large perivascular lymphoid aggregates also in 8 cases of non-MoM THR cases. Conclusion: Extensive lymphocytic infiltration in the periprosthetic tissue around MoM THR is predominant histological pattern; however, perivascular lymphoid aggregates are not exclusive characteristic in tissue around MoM prostheses. | |
| Keywords | ortopedija obprotezno tkivo kolčne proteze orthopedic surgeries hip prostheses periprosthetic tissue Histological characteristics |